Natural and Synthetic Polymers as Inhibitors of Drug Efflux Pumps

Targeting drug-efflux pumps -- a pharmacoinformatic approach.

In line with our studies on propafenone-type inhibitors of P-glycoprotein (P-gp), we applied several methods to approach virtual screening tools for identification of new P-gp inhibitors on one hand and the molecular basis of ligand-protein interaction on the other hand. For virtual screening, a combination of autocorrelation vectors and selforganising artificial neural networks proved extremel...

Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily.

Inhibitors of drug efflux pumps have great potential as pharmacological agents that restore the drug susceptibility of multidrug resistant bacterial pathogens. Most attention has been focused on the discovery of small molecules that inhibit the resistance nodulation division (RND) family drug efflux pumps in Gram-negative bacteria. The prototypical inhibitor of RND-family efflux pumps in Gram-n...

Development of Efflux Pumps and Inhibitors (EPIs) in A. baumanii

Acinetobacter baumanii is a Gram-negative, non-fermenting, oxidase-negative and non-motile coccobacillus, [1]. It can survive in water, soil, surface of skin and hospital environment. It cause a series of opportunistic infections such as epidemic pneumonia, skin and soft tissue infections, bacteraemia, urinary tract infections and septicemia app:addword:septicemia in immunocompromised patients,...

Natural and Synthetic Biomedical Polymers

Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps.

Synergistic effects have previously been observed for a natural compound, tetrandrine (TET), with fluconazole (FLC) in vitro and in the treatment of Candida albicans-infected mice. To investigate the mechanisms of these synergistic effects, 16 strains of C. albicans from the same parent but with different FLC sensitivities were examined using flow cytometry and fluorescent spectrophotometry. Rh...